Depends on you really. I know some people save it for the end, I personally always smooth as I go. I'd recommend smoothing as you go, as it helps you see where a smoothing error will occur, and you'll be able to fix it sooner. Instead of having to go back and fix things that might affect other parts of the model. Also, if it's on both sides you'll need to fix both sides, and it's much easier while you have the one half of symmetry.
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